Bke virus dna pcr

Increasing viral load and sustained viremia have been associated with development of nephropathy post-renal transplant. Urine is the specimen of choice for initial BK virus testing as positivity may provide early evidence of infection. If urine tests positive for BK virus, the blood specimen will be tested in the following run. If the urine tests negative for BK virus, blood testing is canceled.

This is from the anti-rejection medicines. It can damage your new kidney and cause your body to reject it. Your healthcare provider will check for signs of the virus in your system. They will check both before and after receiving your kidney transplant.

Symptoms may include:. Having any of these symptoms could be a sign of infection. This can affect the success of your kidney transplant. It is important to tell your healthcare provider if you notice any signs of infection. Your healthcare provider will decide how often to check you for BK virus and other infections. May include disease information, patient result explanation, recommendations, details of testing, associated diseases, explanation of possible patient results.

Compliance Category. Note Additional information related to the test. Hotline History View Hotline History. Hotline History. Date of Change. CPT codes are provided only as guidance to assist clients with billing. CPT coding is the sole responsibility of the billing party. Click here for your pricing. Components Components of test. Currently, there is no FDA-approved antiviral agent or treatment for BKVAN or BKV-associated hemorrhagic cystitis, and the main treatment is to decrease the immunosuppression, with the risk of acute rejection of the kidney graft.

After BK reactivation, the virus is first detectable in the urine, with viremia developing several weeks later. An "Inconclusive" result indicates that the presence or absence of BKV DNA in the plasma specimen could not be determined with certainty after repeat testing in the laboratory, possibly due to polymerase chain reaction inhibition or presence of interfering substance. Submission of a new specimen for testing is recommended if clinically indicated.

A single "Undetected" test result does not necessarily rule out the presence BKV infection or reactivation. Am J Transplant. Clin Transplant. Transplant Research and Risk Management. This dual-target polymerase chain reaction PCR assay amplifies 2 highly-conserved target regions within the BKV genome small t-antigen and VP2 regions for real-time detection and quantification by 2 target-specific TaqMan probes.

Fluorescent reporter dye-labeled TaqMan probes hybridized to the complementary BKV target sequences and DNA-QS sequence undergo hydrolysis during PCR amplification step to generate fluorescent signal detected in 3 different dye channels. Monday through Saturday. This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions.

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